Signs of Selective Pressure on Genetic Variants Affecting Human Height
نویسندگان
چکیده
منابع مشابه
Signs of Selective Pressure on Genetic Variants Affecting Human Height
Many decades of scientific investigation have proved the role of selective pressure in Homo Sapiens at least at the level of individual genes or loci. Nevertheless, there are examples of polygenic traits that are bound to be under selection, but studies devoted to apply population genetics methods to unveil such occurrence are still lacking. Stature provides a relevant example of well-studied p...
متن کاملSignatures of natural selection on genetic variants affecting complex human traits☆
It has recently been hypothesized that polygenic adaptation, resulting in modest allele frequency changes at many loci, could be a major mechanism behind the adaptation of complex phenotypes in human populations. Here we leverage the large number of variants that have been identified through genome-wide association (GWA) studies to comprehensively study signatures of natural selection on geneti...
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2 The input data set 2 2.1 The genotype data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.2 The expression data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.3 The SNP marker position data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.4 The transcripts model data . . . . . . . . . . . . . . . . . . . . . ...
متن کاملPolymorphic regions affecting human height also control stature in cattle.
Orthologous positions of 55 genes associated with height in four human populations were located on the bovine genome. Single nucleotide polymorphisms close to eight of these genes were significantly associated with stature in cattle (Bos taurus and Bos indicus). This suggests that these genes may contribute to controlling stature across mammalian species.
متن کاملRare and low-frequency coding variants alter human adult height
Human height is a highly heritable, polygenic trait1,2. The contribution of common DNA sequence variation to inter-individual differences in adult height has been systematically evaluated through genome-wide association studies (GWAS). This approach has thus far identified 697 independent variants located within 423 loci that together explain around 20% of the heritability of height3. As is typ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0027588